Loading TrenasCycles…
Investigational GH secretagogue / small molecule
Ibutamoren
MK-677, or ibutamoren, is an experimental oral growth-hormone booster, not a peptide. People discuss it for appetite, fuller muscles and weight gain. A human trial found more fat-free weight, but not more strength; water can contribute to the fuller look. Hunger, swelling and higher blood sugar are the main drawbacks.
Randomized trial in 65 healthy adults aged 60–81, not a bodybuilding recommendation. The study's longer crossover follow-up does not establish a consumer cycle.
Human trials found increased GH, IGF-1 and fat-free mass in selected populations, but the older-adult trial did not show improved strength or function.
Increased hunger, water retention, edema, numbness or carpal-tunnel-like symptoms, higher glucose and reduced insulin sensitivity, plus unapproved-product quality risk.
Glucose and insulin sensitivity, edema, weight, appetite, neurologic compression symptoms and IGF-1 where clinically relevant.
Investigational and not approved as a bodybuilding, anti-aging or general wellness medicine.
Other aliases: Ibutamoren · MK 677 · MK677
MK-677 increased GH, IGF-1 and fat-free mass, but did not improve strength or function.
Older-adult population; fasting glucose rose, insulin sensitivity fell, and edema, appetite and muscle symptoms occurred.
Original source ↗MK-677 increased GH secretion, fat-free mass and energy expenditure over two months.
Short study in obesity; it does not establish durable bodybuilding benefit or long-term safety.
Original source ↗