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Thyroid hormone

T3

liothyronine

Rundown

T3 is active thyroid hormone, used nonmedically to push metabolism and lose weight. That weight loss can include muscle, not just fat. Unlike T4, it does not need to be converted into active thyroid hormone first. Too much can cause a racing heart, anxiety, overheating and bone loss, especially alongside stimulants.

Ratings

Muscle gain1/10

Fullness1/10

Bloat1/10

Dryness6/10

Hair loss5/10

Mental sides7/10

Physical sides9/10

Overall3/10

Practical details

Medical dose: 25–75 mcg oral liothyronine once daily is the labeled usual adult maintenance range
Medical treatment duration: Ongoing replacement when indicated; individualized rather than cycled

CYTOMEL label for adult hypothyroidism, adjusted to clinical and laboratory findings. Cardiac disease and older age require different starting considerations; this is not a cutting or weight-loss recommendation.

Known for: Active thyroid-hormone replacement · Increased metabolism when excessive · Direct T3 rather than T4 conversion
Main drawbacks: Palpitations and cardiac risk
Muscle loss, anxiety and heat intolerance with excess
Bone loss and stimulant interactions

Research & sources

Evidence

The official label warns that euthyroid use for weight loss is ineffective at ordinary replacement exposure and toxic at higher exposure.

Interactions & monitoring

Tachycardia/arrhythmia, angina, bone loss, muscle wasting, anxiety, heat intolerance and thyroid-axis suppression.

TSH, free T4/T3 only under clinical care; heart rate/rhythm; chest pain; bone risk with prolonged excess.

Medical context

Prescription treatment for hypothyroidism and selected thyroid indications. Boxed warning: not for obesity or weight loss.

Sources

FDA liothyronine label

Boxed warning states thyroid hormones are not for obesity/weight loss.

Label does not cover illicit products.

Original source ↗

Compounds

Thyroid hormone

T3

liothyronine

Rundown

Ratings

Muscle gain1/10

Fullness1/10

Bloat1/10

Dryness6/10

Hair loss5/10

Mental sides7/10

Physical sides9/10

Overall3/10

Practical details

Medical dose: 25–75 mcg oral liothyronine once daily is the labeled usual adult maintenance range
Medical treatment duration: Ongoing replacement when indicated; individualized rather than cycled

Known for: Active thyroid-hormone replacement · Increased metabolism when excessive · Direct T3 rather than T4 conversion
Main drawbacks: Palpitations and cardiac risk
Muscle loss, anxiety and heat intolerance with excess
Bone loss and stimulant interactions

Research & sources

Evidence

The official label warns that euthyroid use for weight loss is ineffective at ordinary replacement exposure and toxic at higher exposure.

Interactions & monitoring

Tachycardia/arrhythmia, angina, bone loss, muscle wasting, anxiety, heat intolerance and thyroid-axis suppression.

TSH, free T4/T3 only under clinical care; heart rate/rhythm; chest pain; bone risk with prolonged excess.

Medical context

Prescription treatment for hypothyroidism and selected thyroid indications. Boxed warning: not for obesity or weight loss.

Sources

FDA liothyronine label

Boxed warning states thyroid hormones are not for obesity/weight loss.

Label does not cover illicit products.

Original source ↗

Rundown

Practical details

Evidence

Interactions & monitoring

Medical context

Sources

FDA liothyronine label

Clenbuterol

DNP

Cardarine

Rundown

Practical details

Evidence

Interactions & monitoring

Medical context

Sources

FDA liothyronine label

Clenbuterol

DNP

Cardarine