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Thyroid hormone

T4

levothyroxine

Rundown

T4 replaces missing thyroid hormone and helps bring a slow metabolism back toward normal. The body converts it into active T3, so it is not an immediate stimulant. Extra T4 is not a useful fat-loss shortcut when thyroid function is already normal. Too much can cause a racing heart, muscle weakness, anxiety and bone loss.

Ratings

Muscle gain1/10

Fullness1/10

Bloat1/10

Dryness5/10

Hair loss5/10

Mental sides6/10

Physical sides8/10

Overall3/10

Practical details

Medical dose: About 1.6 mcg/kg oral levothyroxine daily is the labeled full-replacement estimate for adults; many need less
Medical treatment duration: Ongoing replacement when indicated; the full effect of a given dose may take 4–6 weeks

Current LEVO-T label for adult hypothyroidism. Age, cardiac disease, laboratory results and interactions determine the actual prescription; the weight-based estimate is not a weight-loss dose or personal recommendation.

Known for: Long-term thyroid-hormone replacement · Conversion to active T3 · Gradual therapeutic response
Main drawbacks: Palpitations and arrhythmia risk with excess
Absorption interactions
Muscle weakness and bone loss with over-replacement

Research & sources

Evidence

The official label warns against weight-loss use and documents cardiac, skeletal and metabolic harm from over-replacement.

Interactions & monitoring

Tachycardia/arrhythmia, angina, bone loss, anxiety, heat intolerance and thyroid-axis disruption.

TSH and free T4 under clinical care; heart rate/rhythm; symptoms of over-replacement; bone risk.

Medical context

Prescription replacement for hypothyroidism. Boxed warning: not for obesity or weight loss.

Sources

FDA levothyroxine label ↗

FDA levothyroxine label

Boxed warning states thyroid hormones are not for obesity/weight loss.

Product-specific label.

Original source ↗

Compounds

Thyroid hormone

T4

levothyroxine

Rundown

Ratings

Muscle gain1/10

Fullness1/10

Bloat1/10

Dryness5/10

Hair loss5/10

Mental sides6/10

Physical sides8/10

Overall3/10

Practical details

Medical dose: About 1.6 mcg/kg oral levothyroxine daily is the labeled full-replacement estimate for adults; many need less
Medical treatment duration: Ongoing replacement when indicated; the full effect of a given dose may take 4–6 weeks

Known for: Long-term thyroid-hormone replacement · Conversion to active T3 · Gradual therapeutic response
Main drawbacks: Palpitations and arrhythmia risk with excess
Absorption interactions
Muscle weakness and bone loss with over-replacement

Research & sources

Evidence

The official label warns against weight-loss use and documents cardiac, skeletal and metabolic harm from over-replacement.

Interactions & monitoring

Tachycardia/arrhythmia, angina, bone loss, anxiety, heat intolerance and thyroid-axis disruption.

TSH and free T4 under clinical care; heart rate/rhythm; symptoms of over-replacement; bone risk.

Medical context

Prescription replacement for hypothyroidism. Boxed warning: not for obesity or weight loss.

Sources

FDA levothyroxine label ↗

FDA levothyroxine label

Boxed warning states thyroid hormones are not for obesity/weight loss.

Product-specific label.

Original source ↗

Rundown

Practical details

Evidence

Interactions & monitoring

Medical context

Sources

FDA levothyroxine label

Clenbuterol

DNP

Cardarine

Rundown

Practical details

Evidence

Interactions & monitoring

Medical context

Sources

FDA levothyroxine label

Clenbuterol

DNP

Cardarine