Cardiovascular toxicity of illicit anabolic-androgenic steroid use
Long-term AAS use was associated with myocardial dysfunction and coronary atherosclerosis.
Observational; exposure self-selected.
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Anabolic-androgenic steroid
tren
Trenbolone has a reputation for strong muscle-and-strength gains and a harder look. Those are user reports, not results from controlled human bodybuilding trials. Its main tradeoff is how rough it can feel: poor sleep, irritability and mood changes are common complaints in user research. The shorter acetate ester does not remove those problems or the heart-health concerns.
Human evidence is mainly observational or case-based. Recent studies associate use with psychological distress/aggression and broader health harms, but causation and product purity are limitations.
Class-wide AAS risks plus insomnia, sweating, mood/behavior changes, sexual/reproductive suppression, adverse lipids, blood pressure and possible cardiac injury.
Blood pressure; CBC; HDL/LDL/triglycerides; liver/kidney markers; mood/sleep; reproductive hormones.
Not approved for human use. Direct controlled human safety or performance trials are lacking.
Other aliases: tren · trenbolone acetate/enanthate
Long-term AAS use was associated with myocardial dysfunction and coronary atherosclerosis.
Observational; exposure self-selected.
Original source ↗AAS use was associated with increased cardiovascular-disease outcomes.
Observational; residual confounding possible.
Original source ↗Use correlated with psychological distress and aggression measures.
Self-report; does not prove causation.
Original source ↗Describes potent androgenic/anabolic activity and tissue-selectivity hypotheses.
Not controlled human safety evidence.
Original source ↗