Cardiovascular toxicity of illicit anabolic-androgenic steroid use
Long-term AAS use was associated with myocardial dysfunction and coronary atherosclerosis.
Observational; exposure self-selected.
Original source ↗Loading TrenasCycles…
TrenasCycles
Loading TrenasCycles…
Anabolic-androgenic steroid
oxandrolone
Anavar is an oral steroid used for strength and lean-mass gains, especially when dieting. It has a less-watery reputation than the big mass-building orals, although measured gains can still include water. It is not simply a fat burner. Main downsides are worse cholesterol, liver-enzyme changes and suppressed natural testosterone.
Randomized trial in 32 men aged 60–87. Strength and lean-mass changes were measured by 6 weeks, but this does not establish a cosmetic onset or a recommended cutting cycle for younger athletes.
Randomized burn studies found benefits in selected clinical settings, while liver-enzyme changes occurred. These results do not transfer directly to healthy physique users.
Liver injury, marked HDL reduction/LDL increase, gonadal suppression, virilization and cardiovascular risk.
AST/ALT/bilirubin; HDL/LDL/triglycerides; blood pressure; reproductive hormones; signs of virilization.
Former/historical prescription uses include catabolic weight loss and severe burns; regulatory status varies. Not approved for bodybuilding.
Long-term AAS use was associated with myocardial dysfunction and coronary atherosclerosis.
Observational; exposure self-selected.
Original source ↗Improved selected recovery/body-composition outcomes.
Catabolic clinical population.
Original source ↗Reported long-term recovery-related outcomes.
Pediatric burn care; not performance use.
Original source ↗Liver enzymes increased during treatment in a subset.
Illness and co-medications may confound.
Original source ↗