IGF-1 LR3 is a research growth-factor peptide marketed for muscle growth. Its modified structure makes it different from ordinary IGF-1 and approved mecasermin. There is no good controlled human evidence showing what muscle gains users can expect. Uncertain blood-sugar effects and degraded or inconsistent products are the main concerns.
Ratings
Muscle gain7/10
Fullness7/10
Bloat5/10
Dryness5/10
Hair loss2/10
Mental sides3/10
Physical sides9/10
Overall4/10
Practical details
Known for
Muscle-growth claims · Modified IGF-1 · Research peptide
Main drawbacks
Blood-sugar effects not well established
No reliable human muscle-gain data
Degraded or oxidized research products
Research & sources
Evidence
No controlled human bodybuilding trials establish efficacy or safety. Evidence about prescription mecasermin, ordinary recombinant IGF-1 or circulating IGF-1 cannot be transferred to LR3.
Interactions & monitoring
Hypoglycemia, edema, headache, tissue-growth concerns, unknown long-term cancer and cardiovascular implications, and unregulated-product and injection risks.
Urgent assessment for symptomatic hypoglycemia; glucose, edema and unexplained tissue-growth symptoms require clinical context. No monitoring scheme establishes safe use.
Medical context
Never approved for human use and prohibited in sport; black-market products may be oxidized, mislabeled or otherwise poor quality.
Other aliases: IGF LR3 · Long R3 IGF-1 · Long R3 Insulin-like Growth Factor 1